Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders six months after the death of his friend and partner, Sherlock Holmes, at the hands of Moriarty.

Abby Walker's husband is murdered before her eyes. On her quest for revenge, Abby crosses paths with Hoyt Rawlins. Abby and Hoyt's journey takes them to Independence, Texas, where they encounter residents running from their own pasts.

Trás descobrir que seus pais são viliões, um grupo de adolescentes fugem de casa para redimir as ações de seus pais é descobrir segredos de seus origens.